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Symplicity® Catheter System™ - Symplicity® Catheter - Symplicity® Generator Clinical Trials Publications Presentation Tools

Together, we're advancing not just a product, but an entire field. 

The Sympathetic Renal Denervation (RDN) Treatment has its roots in surgical sympathectomy techniques dating back to the 1930s. However, the Symplicity® Catheter System represents the first time that physicians have been able to target renal nerves specifically via a catheter-based intervention.

This endovascualr approach opens the door to better understanding the relationship between sympathetic hyperactivity and hypertension. Ardian remains committed to publishing the results of our research so that as we learn, everyone learns.

To learn more about our research, see the publications and resources listed below:

Scientific Journal Publications About Renal Denervation Treatment

Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT, Esler M. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373(9671):1275-1281.

Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD. Renal Sympathetic-Nerve Ablation for Uncontrolled Hypertension. N Engl J Med. 2009;361(9):932-934.

Schlaich MP, Sobotka PA, Krum H, Whitbourn R, Walton A, Esler MD. Renal Denervation as a Therapeutic Approach for Hypertension. Novel Implications for an Old Concept. Hypertension. 2009;54(6):1195-1201.

Esler M. The 2009 Carl Ludwig Lecture: pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management. J Appl Physiol. 2010;108(2):227-237.

Dibona GF, Esler MD. Translational Medicine: the antihypertensive effect of renal denervation. Am J Physiol Regul Integr Comp Physiol. 2010;298(2):R245-253.

Katholi RE, Rocha-Singh KJ. The role of renal sympathetic nerves in hypertension: has percutaneous renal denervation refocused attention on their clinical significance? Prog Cardiovasc Dis. 2009;52(3):243-248.

Doumas M, Faselis C, Papademetriou V. Renal Sympathetic Denervation and Systemic Hypertension. Am J Cardiol. 2010;105(4):570-576.

Schlaich MP, Krum H, Sobotka PA. Renal sympathetic nerve ablation: the new frontier in the treatment of hypertension. Curr Hypertens Rep. 2010;12(1):39-46.

Katholi RE, Rocha-Singh KJ, Goswami NJ, Sobotka PA. Renal nerves in the maintenance of hypertension: A potential therapeutic target. Curr Hypertens Rep. 2010;12:196-204.

Esler MD, Lambert EA, Schlaich M, Navar LG. The Dominant Contributor to Systemic Hypertension: Chronic Activation of the Sympathetic Nervous System vs Activation of the Intrarenal Renin-Angiotensin System. J Appl Physiol. 2010.

Fisher JP, Fadel PJ. Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension. Exp Physiol. 2010;95(5):572-580.

Lambert GW, Straznicky NE, Lambert EA, Dixon JB, Schlaich MP. Sympathetic nervous activation in obesity and the metabolic syndrome--causes, consequences and therapeutic implications. Pharmacol Ther. 2010;126:159-172.

Masuo K, Lambert GW, Esler MD, Rakugi H, Ogihara T, Schlaich MP. The role of sympathetic nervous activity in renal injury and end-stage renal disease. Hypertens Res. 2010;33:521-528.

Schlaich MP, Socratous F, Hennebry S, Eikelis N, Lambert EA, Straznicky N, Esler MD, Lambert GW. Sympathetic activation in chronic renal failure. J Am Soc Nephrol. 2009;20(5):933-939.

Bock JS, Gottlieb SS. Cardiorenal syndrome: New perspectives. Circulation. 2010;121:2592-2600.

Goldsmith SR, Sobotka PA, Bart BA. The sympathorenal axis in hypertension and heart failure. Journal of Cardiac Failure. 2010;16(5):369-373.

Grassi G. Assessment of sympathetic cardiovascular drive in human hypertension: achievements and perspectives. Hypertension. 2009;54(4):690-697.

Ritz E. New approaches to pathogenesis and management of hypertension. Clin J Am Soc Nephrol. 2009;4(12):1886-1891.

Ritz E, Rump LC. Control of sympathetic activity--new insights; new therapeutic targets? Nephrol Dial Transplant. 2010;25(4):1048-1050.

Joyner MJ, Charkoudian N, Wallin BG. Sympathetic nervous system and blood pressure in humans: Individualized patterns of regulation and their implications. Hypertension. 2010;56:10-16.

Mann JF. Whats new in hypertension 2009? Nephrol Dial Transplant. 2010;25(1):37-41.

Bravo EL, Rafey MA, Nally JV, Jr. Renal denervation for resistant hypertension. Am J Kidney Dis. 2009;54(5):795-797.

King A. Hypertension: RF ablation of renal nerves. Nature Reviews Nephrology. 2009;5:364.

Doumas M, Douma S. Interventional management of resistant hypertension. Lancet. 2009;373(9671):1228-1230.

Paulis L. Novel therapeutic targets for hypertension. Nat Rev Cardiol. 2010.

OBrien E. Renal sympathetic denervation for resistant hypertension. Lancet. 2009;373(9681):2109; author reply 2109-2110.

Titze S, Uder M, Schmieder R. Renal nerve ablation: innovative therapy for treatment of resistant hypertension. MMW Fortschr Med. 2009;151(42):52-53.


Scientific Presentations and Posters About Renal Denervation Treatment

Schlaich MP on on behalf of the Symplicity HTN-1 Investigators. Two-Year Durability of BP Reduction with Catheter-based Renal Sympathetic Denervation. European Society of Hypertension (ESH) 2010.

Sievert, H Symplicity HTN-1: 18-month Results of Sympathetic Renal Denervation in Resistant Hypertension EuroPCR 2010 May 2010

Godlewski, J Case Presentation: Catheter-based Treatment for Hypertension EuroPCR 2010 May 2010

Scheinert, D Renal Denervation by RF Ablation in Patients with Refractory Hypertension Leipzig Interventional Course (LINC) 2010 January 2010

Rocha-Singh, K Clinical Trial Data That May Change Your Practice- Renal Sympathetic Nerve Ablation for Resistant Hypertension: Results of the US Pilot Trial Vascular Interventional Advances (VIVA) 2009 October 2009

Krum, H Ardian SYMPLICITY I: One Year Results Sympathetic Renal Denervation in Resistant Hypertension Transcatheter Cardiovascular Therapeutics (TCT) Meeting September 2009

Whitbourn, R Out of the Box Concepts...Renal Sympathetic Denervation for the Treatment of Resistant Hypertension Transcatheter Cardiovascular Therapeutics (TCT) Meeting September 2009

Rocha-Singh, K BP Normalization & Medication Reduction in a Patient with Resistant Hypertension Treated with Symplicity Catheter-based Renal Denervation Transcatheter Cardiovascular Therapeutics (TCT) Meeting September 2009

Sobotka, P Top New Treatment Concept for 2009: Catheter-Based RF Ablation of the Renal Sympathetic Nerves for the Treatment of Hypertension Transcatheter Cardiovascular Therapeutics (TCT) Meeting 2009

Sobotka, P Selective Renal Sympathetic Denervation for Hypertension and Chronic Heart Failure Transcatheter Cardiovascular Therapeutics (TCT) Meeting 2009

Esler, M Catheter-Based Renal Denervation Reduces Total Body and Renal Noradrenaline Spillover and Blood Pressure in Resistant Hypertension European Society of Hypertension Meeting June 2009

Schlaich, M Effects of Renal Sympathetic Denervation on Noradrenaline Spillover and Systemic Blood Pressure in Patients with Resistant Hypertension European Society of Hypertension Meeting June 2009

Schlaich, M A Novel Catheter Based Approach to Denervate the Human Kidney Reduces Blood Pressure and Muscle Sympathetic Nerve Activity in a Patient with End Stage Renal Disease and Hypertension European Society of Hypertension Meeting June 2009

Schlaich, M Renal denervation in human disease: novel implications for an old concept Experimental Biology Meeting 266.3 April 2009

Krum H Catheter-Based Renal Sympathetic Denervation in the Management of Resistant Hypertension American College of Cardiology Annual Meeting Presentation March 2009

Whitbourn RJ A Catheter-Based Treatment for Hypertension: ARDIAN Transcatheter Cardiovascular Therapeutics (TCT) Meeting October 2008

Krum H Renal Denervation European Society of Cardiology Annual Meeting Presentation September 2008


Scientific Abstracts About Renal Denervation Treatment

Esler M, Schlaich M, Sobotka P, Whitbourn R, Sadowski J, Bartus K, et al. Catheter-Based Renal Denervation Reduces Total Body and Renal Noradrenaline Spillover and Blood Pressure in Resistant Hypertension. Journal of Hypertension. 2009;27(suppl 4):s167.

Schlaich MP, Krum H, Whitbourn R, Walton T, Lambert GW, Sobotka PA, et al. Effects of Renal Sympathetic Denervation on Noradrenaline Spillover and Systemic Blood Pressure in Patients with Resistant Hypertension. Journal of Hypertension. 2009;27(suppl 4):s154.

Schlaich M, Krum H, Walton T, Lambert E, Lambert G, Sobotka P, et al. A Novel Catheter Based Approach to Denervate the Human Kidney Reduces Blood Pressure and Muscle Sympathetic Nerve Activity in a Patient with End Stage Renal Disease and Hypertension. Journal of Hypertension. 2009;27(suppl 4):s437.


Sympathetic Hyperactivity & Hypertension

Siddiqi L, Joles JA, Grassi G, Blankestijn PJ. Is kidney ischemia the central mechanism in parallel activation of the renin and sympathetic system? J Hypertens. 2009 Jul;27(7):1341-9.

Augustyniak RA, Tuncel M, Zhang W, Toto RD, Victor RG. Sympathetic overactivity as a cause of hypertension in chronic renal failure. J Hypertens. 2002;20(1):3-9.

DiBona GF. Sympathetic nervous system and the kidney in hypertension. Curr Opin Nephrol Hypertens. 2002;11(2):197-200.

Mancia G, Grassi G, Giannattasio C, Seravalle G. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension. 1999;34(4 Pt 2):724-728.


Hypertension Guidelines & Statistics

Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, et al. Heart disease and stroke statistics--2010 update: a report from the american heart association. Circulation. 2010;121(7):e46-e215.

Cutler JA, Sorlie PD, Wolz M, Thom T, Fields LE, Roccella EJ. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004. Hypertension. 2008;52(5):818-827.

Sarafidis PA, Bakris GL. Resistant Hypertension: An Overview of Evaluation and Treatment. Journal of the American College of Cardiology. 2008;52(22):1749-57.

Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the ESC. Eur Heart J. 2007;28(12):1462-1536.

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jr., et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-1252.

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